Open PhD-position in case study A2: Polymer Fibre Tox
The IUF – Leibniz Research Institute for Environmental Medicine investigates the molecular mechanisms through which particles, radiation and environmental chemicals harm human health. The main working areas are environmentally induced aging of the pulmonary system and the skin as well as disturbances of the nervous and immune system. Through development of novel model systems, the IUF contributes to the improvement of risk assessment and the identification of novel strategies for the prevention / therapy of environmentally induced health damage.
The DWI – Leibniz Institute for Interactive Materials, Aachen is a research institute that takes on the challenge of surpassing disciplinary limits and tackling new questions relating to substances and materials that combine technology and nature. It is a location where people with different talents, experiences and skills work together, to learn from each other, and generate new knowledge and new methods to create a better quality of life in our world.
The IUF and DWI are members of the Leibniz Research Alliance Advanced Materials Safety which aims to advance the design and sustainable development of functional and safe materials. In the framework of this alliance the IUF and the DWI working group “Particles, Inflammation and Genome Integrity” are looking for
a PhD-student (m/f/d)
for the research project „Polymer Fibre Tox“.
The project aims to investigate the potential adverse human health effects and mechanisms of toxicity of high performance (ultrafine) polymer fibres (HPFs) and their additives caused by their fragmentation and subsequent ingestion and inhalation. The research combines two complementary areas. The first deals with preparation, characterization and labelling of well-defined nano- and micro-fragments of HPFs. The second studies the phagocytosis and toxicity of fragments as a function of their shape, size and composition using 3D in vitro cell models of the human intestine and lung. The project will be implemented in an interdisciplinary setting involving research at the IUF (24 months) and research stays at the DWI in Aachen (12 months).
We are looking for an applicant with a high level of commitment, team spirit and organisational skills. The applicant should have a completed Master’s degree in life sciences, ideally in the fields of biotechnology and toxicology. Hands on experience with cell culture, molecular biological, biochemical and immunohistochemical methods as well as characterization of polymeric particles is a plus. A very good command of written and spoken English is a prerequisite.
The position is limited for the duration of 3 years. The employment relationship is governed by the provisions of the Collective Agreement for Employees of the Federal States (TV-L). The weekly working time is 25 hours and 54 minutes.
Please address your application (letter of motivation, CV, references, qualification certificates), preferably electronically to firstname.lastname@example.org:Dr. Roel Schins
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
Link to the job advertisement at IUF: https://iuf-duesseldorf.de/phd-student-f-m-d/